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acetyl histone h2b  (Cell Signaling Technology Inc)


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    Structured Review

    Cell Signaling Technology Inc acetyl histone h2b
    Hydroxamic acid derivatives 7d and 7p induce inhibition of histone deacetylase (HDAC) class I and II enzyme activity in THP‐1 cells. (a) The inhibitory effects of vorinostat 1 , 7d , and 7p on the enzyme activity of HDAC class I and II were determined using the HDAC‐Glo™ I/II Assay. The results are expressed as the mean ± SD of three independent experiments. The levels of histone H2A, <t>H2B,</t> H3, or H4 acetylation after (b) 24 h or (c) 48 h of treatment with vorinostat 1 , 7d , and 7p were determined by immunoblot analysis using appropriate antibodies. Representative immunoblots of one of three experiments are shown. CTRL is a drug‐free control.
    Acetyl Histone H2b, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 28 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/acetyl histone h2b/product/Cell Signaling Technology Inc
    Average 94 stars, based on 28 article reviews
    acetyl histone h2b - by Bioz Stars, 2026-02
    94/100 stars

    Images

    1) Product Images from "New potent N ‐hydroxycinnamamide‐based histone deacetylase inhibitors suppress proliferation and trigger apoptosis in THP‐1 leukaemia cells"

    Article Title: New potent N ‐hydroxycinnamamide‐based histone deacetylase inhibitors suppress proliferation and trigger apoptosis in THP‐1 leukaemia cells

    Journal: Archiv Der Pharmazie

    doi: 10.1002/ardp.202400889

    Hydroxamic acid derivatives 7d and 7p induce inhibition of histone deacetylase (HDAC) class I and II enzyme activity in THP‐1 cells. (a) The inhibitory effects of vorinostat 1 , 7d , and 7p on the enzyme activity of HDAC class I and II were determined using the HDAC‐Glo™ I/II Assay. The results are expressed as the mean ± SD of three independent experiments. The levels of histone H2A, H2B, H3, or H4 acetylation after (b) 24 h or (c) 48 h of treatment with vorinostat 1 , 7d , and 7p were determined by immunoblot analysis using appropriate antibodies. Representative immunoblots of one of three experiments are shown. CTRL is a drug‐free control.
    Figure Legend Snippet: Hydroxamic acid derivatives 7d and 7p induce inhibition of histone deacetylase (HDAC) class I and II enzyme activity in THP‐1 cells. (a) The inhibitory effects of vorinostat 1 , 7d , and 7p on the enzyme activity of HDAC class I and II were determined using the HDAC‐Glo™ I/II Assay. The results are expressed as the mean ± SD of three independent experiments. The levels of histone H2A, H2B, H3, or H4 acetylation after (b) 24 h or (c) 48 h of treatment with vorinostat 1 , 7d , and 7p were determined by immunoblot analysis using appropriate antibodies. Representative immunoblots of one of three experiments are shown. CTRL is a drug‐free control.

    Techniques Used: Inhibition, Histone Deacetylase Assay, Activity Assay, Ii Assay, Western Blot, Control



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    Image Search Results


    Hydroxamic acid derivatives 7d and 7p induce inhibition of histone deacetylase (HDAC) class I and II enzyme activity in THP‐1 cells. (a) The inhibitory effects of vorinostat 1 , 7d , and 7p on the enzyme activity of HDAC class I and II were determined using the HDAC‐Glo™ I/II Assay. The results are expressed as the mean ± SD of three independent experiments. The levels of histone H2A, H2B, H3, or H4 acetylation after (b) 24 h or (c) 48 h of treatment with vorinostat 1 , 7d , and 7p were determined by immunoblot analysis using appropriate antibodies. Representative immunoblots of one of three experiments are shown. CTRL is a drug‐free control.

    Journal: Archiv Der Pharmazie

    Article Title: New potent N ‐hydroxycinnamamide‐based histone deacetylase inhibitors suppress proliferation and trigger apoptosis in THP‐1 leukaemia cells

    doi: 10.1002/ardp.202400889

    Figure Lengend Snippet: Hydroxamic acid derivatives 7d and 7p induce inhibition of histone deacetylase (HDAC) class I and II enzyme activity in THP‐1 cells. (a) The inhibitory effects of vorinostat 1 , 7d , and 7p on the enzyme activity of HDAC class I and II were determined using the HDAC‐Glo™ I/II Assay. The results are expressed as the mean ± SD of three independent experiments. The levels of histone H2A, H2B, H3, or H4 acetylation after (b) 24 h or (c) 48 h of treatment with vorinostat 1 , 7d , and 7p were determined by immunoblot analysis using appropriate antibodies. Representative immunoblots of one of three experiments are shown. CTRL is a drug‐free control.

    Article Snippet: [ , ] Membranes were stained overnight at 4°C with appropriate primary antibodies: anti‐β‐actin antibody (Santa Cruz Biotechnology), antibodies against cyclin E1 (Clone: HE12, Cat. #: sc‐247), p‐Rb [Ser 807/811] (sc‐16670‐R), cleaved PARP (D64E10, 5625), acetyl‐histone H2A [Lys5] (2576), acetyl‐histone H2B [Lys5] (D5H1S, 12799), acetyl‐histone H3 [Lys9] (C5B11, 9649) and acetyl‐histone H4 [Lys8] (2594) were purchased Cell Signalling Technology.

    Techniques: Inhibition, Histone Deacetylase Assay, Activity Assay, Ii Assay, Western Blot, Control